Looking to stretch its unbeaten run to 37 matches, French leader Paris Saint-Germain will visit struggling Evian on Wednesday.
PSG is four points ahead of Lille, which has a tricky match at home to Marseille, and five clear of Monaco, which visits Nice. Both matches are on Tuesday.
Here are five things to know about the midweek round of matches:
Edison Cavani and Zlatan Ibrahimovic were both on target as Paris Saint-Germain beat Lyon 4-0 on Sunday to restore its four-point lead at the top of the French standings.
Cavani opened the scoring and Ibrahimovic added two from the penalty spot. Thiago Silva also scored.
Ibrahimovic is now the top scorer in the league with 11 goals, one more than Cavani, as the duo continue to dispel fears they would not be able to play together.
"Having Cavani makes my game easier," Ibrahimovic said. "If I don't score, he scores. It's something we didn't have last year. He also does a lot of defensive work and he is good for the team. That's what we needed.
"We are stronger this year. If we use Cavani in the right way, it could be good for the team."
Lille's Vincent Enyeama is on the verge of moving into second in the list of goalkeepers in French league history who haven't conceded for the longest time.
Enyeama has not allowed a goal in 945 minutes and surpassed a number of shot-stopping greats with his 10th straight clean sheet in Saturday's 1-0 win at Valenciennes.
The Nigerian is just short of PSG goalkeeper Salvatore Sirigu's second-best mark of 948 from last season and should beat it barring an early shock against Marseille on Tuesday.
Enyeama is still some way off record-holder Gaetan Huard, who went 1,176 minutes without conceding for Bordeaux during the 1992-93 season.
However, Marseille has scored in all but two of its league matches this season and has 23 goals in 15 matches. Only Monaco and PSG have scored more.
Lille is second, four points behind PSG, with Marseille six points further back.