"She's one of the bravest players in the world, maybe the bravest player in the world," O'Reilly said. "And that's why she's able to finish so many goals. She takes us on her back so many games, so I'm so happy she was able to get some in the back of the net tonight."
Wambach's two-goal game came some eight years after she scored five times in a 5-0 victory over Ireland at Houston's Reliant Stadium.
"Somehow, I like Houston," Wambach said. "I like playing here."
Lloyd gave the four-time gold medalists a 2-0 lead in the 62nd minute earlier with a header of her own off Megan Rapinoe's corner kick.
Rodriguez capped the scoring with a 7-yard shot off a save by goalkeeper Wang Fei in the 85th minute.
The exhibition before 15,643 fans at BBVA Compass Stadium was the ninth match in the 10-game Fan Tribute Tour that wraps up Saturday in Boca Raton, Fla., with the third straight game against China.
The top-ranked Americans are 16-0-3 against China dating to 2003.