D.J. Augustin tied it at 20 with a 3-pointer to start the second quarter. Augustin hit another 3 to put the Pacers ahead 24-22, but the lead was short-lived and Portland went up 34-26 on rookie Will Barton's running jumper and layup.
Aldridge made three consecutive long jumpers for a 44-28 lead as Portland broke it open with a 22-4 run. The Blazers led 44-32 at the half.
His dunk made it 55-42 midway through the third quarter.
Lillard's pull-up jumper gave the Blazers a 76-59 lead early in the fourth quarter, but the Blazers' biggest margin of the game was the final score. It was Portland's greatest margin of victory this season.
"It's about time," said Lillard, who did not commit a single turnover in the game.
The Pacers have lost four straight in Portland.
"They came out and played with great desperation. It's very difficult to come out play a really good team on a six-game losing streak," Pacers coach Frank Vogel said. "They came out and brought the fight to us with their defense."
Notes: The Blazers' first poster night of the season got off to a rocky start because of a printing error. The posters, which feature Hickson, won't be ready until next week. Fans with a ticket stub to Wednesday night's game will be able to get one in the team's fan shop. ... Indiana's 32 first-half points were a season-low for a Portland opponent this season. ... Indiana defeated Portland 99-92 on Dec. 5.