The game shifted in the second quarter as Anadarko ripped off 28 points. Quarterback Tyler Melton threw back-to-back touchdowns passes to Wilson and Tanner Dearman in the first half.
Wilson ended the first half with 120 yards rushing on 15 carries, 44 yards receiving and three total touchdowns.
Tuttle quarterback Cooper Koons threw three interceptions and had only three completions in the first half for 39 yards.
Wilson did not re-enter the game after he scored his fourth touchdown in the third quarter. Anadarko (9-0, 5-0) scored its last TD on a 6-yard run by freshman running back Tramayne Wauahdooah.
“If we're going to be one of the best teams, we've got to beat the best,” Anadarko coach Kent Jackson said. “The Tuttles and the Clintons — those guys are the best. Big win.”