"You need one of those dirty ones to start the roll and hopefully I did that," Condra said. "Without (injured centre Jason Spezza) everybody's got to chip in and we've got to do it the dirty way for other things to open up."
Daniel Alfredsson had a chance to open the scoring for the Senators on the power play prior to the two-goal barrage, but the Ottawa captain's one-timer missed the net with Miller at his mercy.
Buffalo had a chance to get back in the game midway through the third when Ottawa's Jim O'Brien went off for holding and Kyle Turris was whistled for high sticking to set up a two-man advantage for 14 seconds. But Anderson and the Senators penalty killers did the job against a Sabres power play that finished the night 0-for-4.
Ottawa's Jakob Silfverberg had a chance to stretch the Senators' lead to three on a power play later in the period, but Miller sprawled to make a diving save at the side of the Buffalo net.
The Sabres held a 13-7 shot advantage in the first period but couldn't solve Anderson.
Ottawa finished 0 for 8 on the power play.
Notes: Ottawa visits Pittsburgh on Wednesday, while Buffalo is home to Boston on Friday. ... Attendance at Scotiabank Place was 18,429.