SAN FRANCISCO (AP) — Joe Montana never did it. Neither did Steve Young or Y.A. Tittle. Even the architect of the West Coast offense, Bill Walsh, could only imagine such a massive mark.
Of all the Hall of Fame quarterbacks and coaches in the history of the San Francisco 49ers, leave it to Alex Smith and Jim Harbaugh to set a new standard.
Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and the 49ers amassed a franchise-record 621 yards in blowing by the Buffalo Bills 45-3 on Sunday.
San Francisco also became the first team in NFL history with 300 yards passing and 300 yards rushing.
"Very cool," Smith said. "When you think of the 49ers, you think of great offense."
Michael Crabtree (seven catches for 113 yards) and Vernon Davis (seven catches for 106 yards) each eclipsed the century mark to pull San Francisco (4-1) into a tie with Arizona for the NFC West lead. Even Randy Moss, rarely targeted in his comeback, caught a pass for 11 yards.
Smith, the 2005 No. 1 overall pick out of Utah, threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career — and first in a victory. The last time came when he had 309 yards in a loss at Philadelphia two years ago — "a completely different world," he said — in former coach Mike Singletary's final season.
"Quarterback was near perfect," Harbaugh said.
The Bills again found themselves on the wrong side of a 49ers record — and quite a few others, too.
Rian Lindell kicked a 31-yard field goal in the first quarter before the 49ers scored the final 42 points to hand Buffalo (2-3) its second straight embarrassing loss. San Francisco's previous best was 598 yards in a 34-31 loss to the Bills on Sept. 13, 1992, which also was Buffalo's worst.
Ryan Fitzpatrick threw for 126 yards and an interception, and the Bills rushed for only 89 yards, most with the game well out of hand once again.
"They flat-out dominated the game from end to end," Fitzpatrick said. "We just got beat bad by a better team today. There was no fancy stuff. They are who they are and they just played better."
The Bills allowed 45 second-half points and 580 total yards in a humiliating 52-28 home loss to New England last week. Beginning a two-week road trip, Buffalo's baggage also traveled to the West Coast.
Since taking a 21-7 lead against the Patriots, Buffalo has been outscored 90-10. The Patriots and 49ers combined to gain 1,201 yards. And with the 49ers shredding the New York Jets last week, they've outscored opponents 79-3 in their last two games.
The Bills became the first team to give up at least 550 yards in consecutive games in the same season since the 1950 New York Yanks.
"I have no answers and no excuses," beleaguered Bills coach Chan Gailey said. "I don't have the answers and I have to find the answers. That's my job."
With the Bills unable to slow anybody down on defense, San Francisco abandoned its usually conservative game plan to deliver a scintillating show in the air.