BOSTON (AP) — Koji Uehara had been perfect for the Red Sox. That all ended on his first pitch to Adam Jones.
Chris Davis hit his sixth homer and Jones drove in two runs, including a tiebreaking double off Uehara, to lead the Baltimore Orioles over Boston 3-2 on Thursday night.
The Orioles broke a 2-all tie on Jones' RBI double in the seventh inning. Manny Machado had a two-out single off reliever Clayton Mortensen (0-1) before Andrew Miller walked Nick Markakis. Jones then lined Uehara's first pitch into the left-field corner.
Red Sox manager John Farrell thought the inning started to fall apart with Miller's walk.
"That's the life of a situational left-hander. He's pressed into action right away," Farrell said. "As effective and consistent as Koji's been, we made a move there and unfortunately it didn't work out."
Before the hit, Uehara hadn't allowed a baserunner in three innings of relief this season.
Davis and Jones extended their torrid starts for the Orioles, who took two of three in Boston. The pair has combined for 30 of Baltimore's 85 hits.
"He had a big night for us, had some big hits when we needed them," Orioles manager Buck Showalter said about Jones, who is 18 for 39 this season (.462).
Boston fill-in starter Alfredo Aceves pitched five innings, allowing two runs and six hits while walking three and striking out four. He took the spot of John Lackey, placed on the 15-day disabled list Wednesday after straining his right biceps in his previous start.
"Right now he's on the line to make the next start," Farrell said.
Dustin Pedroia and Mike Napoli had consecutive RBI singles for the Red Sox, who dropped a series for the first time after taking two of three on the road from both the New York Yankees and Toronto.
Baltimore improved to 1-3 in one-run games after going 29-9 last season.
The teams played on a chilly evening with a game-time temperature of 45 degrees and Fenway Park only about two-thirds full a night after a record sellout streak ended. The paid attendance was 27,704, the smallest crowd at Fenway since April 16, 2003.
Brian Matusz (1-0) struck out the only two batters he faced and got the win. Jim Johnson pitched the ninth in a light rain for his fourth save.