During 28 years with the Astros, Hamilton called Ryan's 4,000th strikeout and Craig Biggio's 3,000th hit.
Known for his catch phrase, ‘Holy Toledo, what a play!' Hamilton primarily called home games starting in 2006 before retiring after the 2012 season.
He has called games from 59 different ballparks and hopes to call one inning this season when the Astros play at Detroit to make it 60.
Earlier in his career, Hamilton called Roger Maris' 61st home run on the White Sox broadcast. He was on the Cardinals broadcast team when Stan Musial hit five homers in a doubleheader in 1954. Musial died last weekend.
“Stan Musial was my favorite player,” Hamilton said. “I think he was the favorite player of a lot of people. He was the greatest ambassador for the game that I've ever known. He had a wonderful life and a wonderful career.”