OSU's Brandon Weeden and the Cowboy receivers against OU's secondary
OSU: Weeden's production has been second to none. His arm strength allows him to make throws other quarterbacks cannot make and his accuracy is underrated. Justin Blackmon is the nation's most consistent receiver and Josh Cooper is a solid No. 2 target. But when Blackmon is not on the field, OSU struggles to have a perimeter threat.
OU: Sooner safeties Quinton Carter and Jonathan Nelson are versatile defenders who can make plays against the run and pass and Jamell Fleming is one of the Big 12's most underrated covermen. But Blackmon has gone against the nation's best and had success and Weeden will test the Sooner secondary unlike any quarterback they've faced in 2010.
OSU's running backs vs OU's linebackers
OSU: The Cowboys have three quality running backs including the nation's No. 5 leading rusher in Kendall Hunter. The only teams who have sold out to stop him (Tulsa, Baylor) gave up over 700 total yards. But the Sooners linebackers could be the most athletic group OSU has faced.
OU: Travis Lewis is one of the Big 12's elite defenders, Tom Wort and Austin Box are solid and Corey Nelson could be a future star. But as talented and athletic as this group is, the Sooners have really struggled to stop the run in recent weeks.
OSU's offensive line vs OU's defensive line
OSU: The Cowboy offensive line has been the key to an OSU attack which ranks No. 1 nationally in total offense. They give Brandon Weeden time to go through his progressions and give Hunter lanes to run through. But this group struggled at times against Texas A&M, which brought pressure similar to what OU will bring to the table.
OU: Jeremy Beal is a problem for any offense, the consistent pressure he provides makes life a lot easier for OU's secondary. An unstoppable pass rusher can be any offense's primary concern. But the Sooners' interior has been hit by the injury bug and former defensive end Pryce Macon could make just his second career start in the interior.