OU's Landry Jones and the Sooners receivers against OSU's secondary.
OU: Jones has been stellar at times this season and is coming off a great game at Baylor. Ryan Broyles is unstoppable and Kenny Stills will have to be accounted for. But Broyles is the only Sooner receiver averaging more than four receptions per game.
OSU: Andrew McGee leads the Big 12 in interceptions while Markelle Martin is one of the league's top safeties. But OSU has true freshman backups at every position and has struggled in pass coverage in multiple games this season.
OU's running backs vs OSU's linebackers
OU: DeMarco Murray brings athleticism and versatility to the table with his pass catching abilities while freshman Roy Finch has emerged as an X factor in the Sooner offense since returning from ankle injury. But Murray has just four games of 100 rushing yards or more and one of more than 115 rushing yards.
OSU: Orie Lemon is one of the Big 12's top linebackers and is the foundation of the Cowboy defense. Justin Gent is solid and OSU's defense has improved in the four games since freshman Shaun Lewis entered the starting lineup including two games holding opponents under 300 total yards. But Murray and Finch both excel in one-on-one situations with linebackers.
OU's offensive line vs OSU's defensive line
OU: The Sooner offensive line has helped OU rank No. 4 nationally in passing yards (324.4), No. 13 in total offense (470.27) and No. 16 in scoring offense (36.3). But they've struggled to create running lanes for DeMarco Murray as OU averages just 3.47 yards per carry this season and allow 1.55 sacks per game.
OSU: Chris Donaldson and Shane Jarka have been solid at defensive tackle after entering the season as a potential question mark while defensive ends Jamie Blatnick, Richetti Jones and Ugo Chinasa have combined for 11 sacks. But OSU lacks the dominant pass rush threat who must be accounted for on every snap.