Coming off a first-round win over Oklahoma State, No. 10 seeded Missouri roared out to a 13-2 lead.
The Tigers built their largest lead (35-23) in the opening seconds of the second half.
The Sooners answered with a 15-0 run to take their first lead with 13 minutes left.
OU would never trail again.
The Sooners pushed their advantage to 47-40, eventually leading by as many as 12 points.
“I don't think we were playing that bad,” Hand said. “We just needed to get out quicker to shooters and knock down some shots. We got lost in the second half, just playing, not worried about losing, not being tight.”
A dominant second half was one of the Sooners' best halves of the season.
OU shot 58 percent after intermission, committed only two turnovers and held Missouri to 31 percent shooting.
“That's how you have to play in this month,” Coale said. “The difference is knowing you can do that and doing it. There's nothing like feeling it. After a half like that they feel it. We hope that can be a springboard.”