Bio Matters: Oklahoma City Hough Ear Institute CEO tunes into noise-induced hearing loss research

Jim Stafford: Dr. Richard Kopke is an ear surgeon and chief executive officer at the Hough Ear Institute, a not-for-profit research organization just south of Integris Baptist Hospital. He recently won the 2014 Researcher Recognition Award from the Oklahoma Bioscience Association.
BY JIM STAFFORD, For The Oklahoman Modified: April 6, 2014 at 9:00 am •  Published: April 6, 2014
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Dr. Richard Kopke leaned across a conference table at Oklahoma City’s Hough Ear Institute to place a piece of paper in front of me. It was a line chart reflecting the hearing loss suffered by a 26-year-old U.S. Marine who served two combat tours in Afghanistan and returned with severe hearing impairment.

“This is the hearing you might see in an 80- or 90-year old man,” Dr. Kopke said. “He’s only 26 and has all of his career ahead of him. What we want to do is prevent all that permanent hearing loss.”

Kopke is an ear surgeon and chief executive officer at the Hough Ear Institute, a not-for-profit research organization just south of Integris Baptist Hospital. He recently won the 2014 Researcher Recognition Award from the Oklahoma Bioscience Association.

The Hough Ear Institute was established in the early 1980s by the Baptist Medical Center foundation to continue the work of Dr. Jack Hough, an internationally respected otologist. In 1997, the Institute became a free-standing research institution and today shares space with the Otologic Medical Clinic.

Kopke and his colleagues at the Hough Ear Institute are working on solutions to noise-induced hearing loss in millions of soldiers, veterans and civilians. Hough Ear has a team of six scientists tackling challenges such as regenerating lost inner ear hair cells that are critical to hearing.

Hearing drug research

After coming to Oklahoma City in 2004, Kopke teamed with Dr. Robert Floyd at the Oklahoma Medical Research Foundation to create an antioxidant drug combination therapy using a compound developed by Floyd, and another called N-acetylcysteine. Antioxidants have been shown to reduce the effects of noise-induced hearing loss.

Tests in animal models were so promising that patents were filed on the formulation and a company called Otologic Pharmaceutics was created.

Hough Ear Institute, OMRF, American BioHealth Group, i2E and Integris Health all were instrumental in starting Otologic, which is now part of Oklahoma City’s Accele Biopharma.

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