The 6-foot-10, 251-pound Griffin didn't do much wrong against the Thunder, scoring 35 points while converting 15 of 20 field-goal attempts. He also had 11 rebounds and six assists for the 61st double-double of his captivating rookie season.
Later this month, Griffin will be a convincing choice as NBA Rookie of the Year.
"Unbelievable," Thunder All-Star Kevin Durant said of Griffin. "The things he was doing, but even if you ask Blake, it wasn't just him. His teammates did a good job of getting him the ball, making him look good sometimes. But that guy's unbelievable. I'm really a big fan of him."
The Clippers went 2-2 against OKC this season, and Griffin averaged 26.8 points, 11.8 rebounds and 4.3 assists while shooting 60.3 percent from the field.
"Defensively, we had some issues on Blake, but a lot of teams in this league do," Thunder coach Scott Brooks said. "The guy's a terrific player. He has a very unique game. He can score around the basket. He can catch anything near the basket, and he can bring the ball up the court and make plays for himself or his team."
Asked if he was surprised about getting booed, Griffin smiled and said: "Not really. The Thunder is these people's team. You're not going to cheer for me just because I'm from Oklahoma. I didn't really expect (to be cheered). I'm sure there's a lot of Oklahoma State fans in the audience."