Behind Jefferson, Walker and Henderson, who combined for 48 points, Charlotte put together two of its best quarters this season in taking command of Saturday's game.
After missing its first two shots of the game, the Bobcats hit 11 straight — four by Jefferson, three by Michael Kidd-Gilchrist, and two each from Henderson and Walker — to pull ahead 23-9 with 5:03 remaining in the first quarter.
"We wanted to double Big Al and take away his post-ups," Lillard said. "Sometimes we didn't even get a chance to double him, and he's already scoring or making good passes out of the post. We were just scrambling the whole time."
The Trail Blazers cut the Bobcats' lead to 10 points four times late in the quarter, the last at 31-21 on Mo Williams' jumper with 54 seconds remaining, and were down 11 points at the end of the quarter.
But Charlotte opened the second quarter with 11 unanswered points, with Josh McRoberts' two free throws with 10:03 left putting the Bobcats up 42-22, their first 20-point lead of the half.
Charlotte took its biggest lead of the half at 26 points late in the second quarter, with Jefferson's layup with 1:43 left capping a 10-3 run for a 67-41 bulge.
"We're going to have a good chance to win if all three of us are playing well offensively," Henderson said, referring to Jefferson and Walker. "We're not always going to score that every night, but if we can play the kind of defense that we did tonight, we should have a good chance to win."
Notes: Stotts had no update on the return of Aldridge, who leads the team in scoring (23.4 points) and rebounding (11.1 per game). He has missed Portland's last five games with a low back contusion. ... The Bobcats (34-36) are in seventh place in the Eastern Conference standings, 1 1/2 games ahead of Atlanta (31-36) and 1 1/2 games behind sixth-place Washington (36-33) with 12 games remaining.