If he had been able to keep playing, there's little doubt Varejao, acquired by Cleveland in 2004 in a trade with Orlando, would have been named an All-Star reserve this week.
Grant pointed out that Varejao's injuries have been unrelated.
"They've all really been freak things," he said. "He's frustrated. We're frustrated for him and with him. We would love to have him out there, particularly the type of year he was having. He's really come into his own as a leader on the court, so it's difficult. But at the same time we believe in him as a guy, we know what he can do. He's played in a lot of big games for us, into the Finals. We'll continue to support him."
Cleveland, which has one of the league's youngest rosters, just completed a 1-4 road trip. The Cavs will host Boston on Tuesday and play 10 of their next 12 games at home.
Varejao's injury has allowed Scott to give extra playing time to second-year forward Tristan Thompson and rookie Tyler Zeller. The Cavs, though, have been plagued by wild inconsistency, especially down the stretch in games they've let slip away.
"We've made strides in the right direction, but we just have to be more consistent game-to-game," said Irving, who is averaging 23.1 points, 5.7 assists and 3.6 rebounds per game. "I say it all the time, we've proven we can play with the best in the league, we just have to put two halves together. We're still figuring that out."
They'll have to do it without Varejao, their never-stopping big man who has managed to stay positive despite his latest medical setback.
"His spirits are up," said Grant. "He's frustrated. He wants to play; he wants to be with his teammates on the court. But he's such a good guy. Every time you see him he's still got that big smile."