That's why the best offensive lines are often the ones that are simply the healthiest. They have had an entire offseason and training camp to grow accustomed to playing with each other.
Of course, rarely is that the case by Week 11 of an NFL season.
"Everybody is a professional and doing their job, and they have to step up," said left tackle Branden Albert, who's also been banged up. "Each game is important. We all know what the situation is, late in the season, November and December. And we have to show up and play."
Offensive coordinator Doug Pederson said Thursday that Fisher and Asamoah would likely be a game-time decision Sunday, though it appears that Asamoah is likely to play. He's at least been a limited participant in practice, while Fisher has been held out of afternoon workouts.
Even if neither of them can go, Pederson feels good about the depth behind them.
"As you look at the fourth quarter of the game the other night, Donald Stephenson goes in and we don't really lose a beat there," Pederson said. "We can move some guys around. Geoff Schwartz is there. We have some veteran guys who we feel very comfortable in what they can do."
Stephenson and Schwartz both said that they're ready to play against the Chargers, just as they've been ready to step in all season. After all, it's the reason they were brought in.
"You know, it's one of those things, me and Geoff prepare like we're starters, so when we go in, there's no surprise about what we need to do or how we communicate," Stephenson said. "So on Sundays when you need to be thrown out there, it pays off."