Mendoza scored the game-tying touchdown early in the fourth quarter, and standout sophomore running back Marquiz Simpkins broke loose for a 27-yard score to put Clinton on top with 2:04 to play. He finished with 119 yards and two touchdowns on 20 carries.
Anadarko drove inside the Clinton 20 in the final seconds, throwing multiple passes into the end zone, but couldn't convert.
After taking a 14-7 lead in the second quarter, Anadarko struggled to move the ball after halftime, accounting for the majority of its 73 second-half yards on the final drive.
It was Clinton's first title since 2007, when Garrison Mendoza and the other seniors were in the eighth grade.
“I've been to so many practices, it's crazy,” he said. “I've known Coach Lee so long, he's like my dad. I'm glad I could do this for him, my family.
“All these fans up there, we did it for them. It's a big deal to me. My brother got one of them. I'm just glad we could get one for all of them.”