The Clippers grabbed a 43-28 lead on Matt Barnes' fast-break basket. Portland struggled offensively and Los Angeles led 53-30 after a 22-2 run — much of it with Griffin taking a break on the bench.
Luke Babbitt hit a 3-pointer for the Blazers at the halftime buzzer, but it didn't make much of a difference and the Clippers led 60-39 at the break.
Portland's reserves, averaging an NBA-low 12.8 points per game, had just eight points in the first half. Their Clippers counterparts scored 25.
The Blazers outscored the Clippers 32-17 in the third quarter, shooting 71 percent for the floor. Batum led the way with 12 points in the quarter.
For the game, Los Angeles shot 53 percent and Portland shot just under 43 percent.
"The first half skewed the whole thing," Blazers coach Terry Stotts said. "The shooting percentages in the first half were very disparate. The third quarter obviously made up for a lot of that in the final tally, but on the whole, we didn't offer much resistance in the first half."
Stotts said the before the game that he anticipating an interesting matchup between perennial All-Star Paul and rookie Lillard, the "old guard and the new guard."
Lillard, quickly building a reputation for his poise in his first year, finished with 16 points. He said Paul spoke to him at times during the game, but it wasn't trash talk: Paul complimented him.
"He can play," Paul said of Lillard after the game. "Portland better hold on to him because they definitely have a prized possession for the future."
NOTES: The Trail Blazers collected donations for the Red Cross to aid victims of Hurricane Sandy. Fans donated over $10,500, while Wells Fargo and the Paul G. Allen foundation each pledged $10,000 for a total of $30,500. ... The Clippers have won seven of their 32 games in Portland. ... The Clippers have won three straight against Portland.