The Clippers took an 82-62 lead into the fourth after outscoring the Spurs 35-21 in the third while shooting 71 percent from the field. Los Angeles dominated the defensive glass 12-2 and its second unit extended the lead to 20 points while Griffin and Paul spent the last few minutes on the bench.
Eric Bledsoe led Los Angeles' reserves with 15 points and Matt Barnes added 12.
"We were so successful because of our defense," Paul said. "When you defend and stop teams, that's when it's fun. If you can defend on a nightly basis in this league you've always got a chance to win. We needed a win like this."
Jordan had three highlight-reel dunks in the third quarter, including a fast break off an alley-oop pass from Paul. The Spurs were held to 37 percent shooting and outscored 22-10 in the paint.
"When D.J.'s on his game, he's tough," Griffin said. "He can score, catch anything, alter and block shots. When he's active like that the paint is controlled by him."
The Clippers led 47-41 at halftime after being ahead by 11 points early in the second. They had just six turnovers after committing 13 in the first half against Cleveland in their previous game. Griffin, Paul and Jordan propelled the Clippers' offense in the second quarter, with Jordan scoring eight points, including consecutive dunks, and Griffin and Paul four each.
Notes: Paul had his right hand wrapped after the game in what he said was a "preventative" measure. He had thumb surgery last summer. ... Ginobili scored nine points in his 670th game with the Spurs, moving him into fifth on the franchise list. ... Griffin played with a sleeve covering his right elbow for the second straight game. He has fluid on his elbow and a stiff neck. ... The Spurs' loss left the Knicks as the NBA's only undefeated team. ... Billy Crystal and Floyd Mayweather Jr. were among the Clippers' fourth sellout crowd of the season and 53rd in a row.