The Clippers last led 10-8 in the first quarter before the Grizzlies took control with Randolph hitting four of his first five shots and all five free throws for 13 points in the quarter.
They tried to make a run late in the third and into the fourth as they have so often to beat Memphis in this series. They got as close as 74-69 with 8:39 left on a pair of free throws by Barnes.
"He came out aggressive, and that's what they needed," Griffin said of Randolph.
Memphis answered with a 7-2 spurt to push the lead back to double digits on a reverse layup by Pondexter off an assist from Randolph.
The Grizzlies outscored the Clippers 23-20 in the first quarter and 24-19 in the second, taking a 47-39 lead into halftime. They hadn't led by more than six in Los Angeles and were up by seven in the first quarter back on their own court. They pushed that to 12 in the second quarter.
Memphis' lead grew to 14 a couple times in the third, the last at 68-54 on a pair of free throws by Pondexter with 1:22 left.
That's when the Clippers went on a 10-2 run featuring back-to-back 3s by Crawford and then Lamar Odom. Ronny Turiaf dunked to pull the Clippers to 70-64 with 11:04 to go.
Pondexter then scored five points for Memphis as he got the rebound after he missed his second free throw attempt and put it back while being fouled by Barnes.
Pondexter added the free throw, pushing Memphis' lead back up to double digits with 10:16 remaining.
Notes: Randolph wound up part of a double foul situation for a third straight game in this series with Griffin late in the game. ... The Clippers hadn't lost in Memphis since Game 5 last year in the playoffs and had won 24 road games during the regular season. ... The Grizzlies went 28 of 38 at the free throw line compared to 21 of 23 for the Clippers. ... The Clippers' 82 points were two shy of a franchise low in the postseason. ... Pondexter had only five total points in the first two games of the series. ... Paul had averaged 23.5 points in the first two games of the series.