Host Virginia Tech (38-20) did not receive one of the eight national seeds. The Hokies face No. 4-seed Connecticut (34-26) in their opener. The winner of the regional is matched with the Baton Rouge Regional, where host LSU is the No. 4 national seed.
OSU (39-17) heads to Louisville, where the Cowboys appeared in a Super Regional in 2007, losing to the Cardinals. The Cowboys will play a Miami (36-23) team that finished fifth in the ACC Coastal Division. In the regional's other opening game, Louisville (46-12) faces Bowling Green (24-29).
The Louisville Regional is matched with the Nashville Regional, where Vanderbilt is the No. 2 national seed. Should the Cowboys advance to play the Commodores, it would be a homecoming of a different sort for OSU coach Josh Holliday, who served as an assistant at Vandy before coming back to the Cowboys where he played and was an assistant.
“You're always curious how the bracket lays out, who's in your regional and where you're paired up,” Holliday said. “The natural thing as a competitor is to look and see where you fit in the whole grand scheme of things.
“But it's Miami first off and then you've got Bowling Green and Louisville. You've got to navigate your way through that. And if you're fortunate to do that, you take on whatever challenge that lies ahead.