Could a spider bite make a superhero?

An Oklahoma Medical Research Foundation scientist discusses the DNA science behind Spider-Man.
By Greg Elwell, For The Oklahoman Published: May 6, 2014
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He spins a web, any size, and catches thieves just like flies. That’s the amazing Spider-Man, created in 1962 by Stan Lee and Steve Ditko, and featured in the new film “The Amazing Spider-Man 2.” One commonality of the story in film, comics and cartoons is that a bite from an arachnid changes a teen into a superhero.

In the comic series that spawned the film, a bite from a radioactive spider transforms puny Peter Parker from a nerd to a wall-climbing, web-spinning crime fighter. While Lee wrote the original story way back in 1962, the idea that Spider-Man’s DNA — deoxyribonucleic acid — was altered by a spider’s bite came in later issues. Still, it got us wondering: Could it really happen?

“The short answer is no,” says Courtney Griffin, Ph.D., an Oklahoma Medical Research Foundation scientist. “The long answer is yes, but with a lot of luck and a lot of spider bites.”

Griffin should know. In the lab, she studies genetics and how it affects the formation of blood vessels. She also examines certain enzymes that turn gene functions on or off and how those actions might lead to disease.

Radiation can absolutely alter DNA, she says. Will it give you the power to climb walls and sense danger? Probably not. For one thing, mutating DNA in one cell doesn’t mean it will mutate the same bit of DNA in the other cells.

“Radiation mutates randomly and could affect any of your 20,000 genes, so instead of super powers, you might end up with cancer,” Griffin says.

“Mutations are unpredictable, and altered DNA might turn on, or turn off, some mechanism that is important to how your body functions. It all depends on where and when the mutation occurs. In this case, it would take multiple bites, and every cell would have to mutate in exactly the same way.”