"In this case, it's just one of those tragedies that's hard to understand," university Provost Rodney Rogers said. "We're reminded in these times that life is very precious."
Spring break begins Saturday for the university of about 18,000 students located about 30 miles south of Toledo.
The accident happened around 2:30 a.m. Truckers had reported the wrong-way driver, and a state highway patrol officer had seen her car and begun a pursuit when the crash happened on the highway, which is divided by a wide, raised grassy median. Initial police calls said people were trapped.
Lein was cited in 2002 in Toledo Municipal Court for a lane changing violation, according to court records. A message was left at a phone listing for her.
The accident recalled a similar tragedy 10 years ago, when six Bowling Green students were killed while returning home from a spring break trip to Florida.
The students, all 19, were returning from Panama City, Fla., on March 15, 2002, when their minivan slid into oncoming traffic and was struck by a tractor-trailer.
Authorities said severe winds and heavy rain may have contributed to the crash, which happened on Interstate 71 in Kentucky.
The sorority sisters' death was the second school tragedy in five days in Ohio. Three students were fatally shot Monday and two others seriously wounded at Chardon High School east of Cleveland. A 17-year-old was charged.
Associated Press writers Thomas J. Sheeran in Cleveland and Andrew Welsh-Huggins in Columbus contributed to this report.