OU's only series win came in 1956, when the No. 1 Sooners romped 40-0 in South Bend.
The most referred-to game in the series came a year later, when the Irish visited Norman on Nov. 16, 1957 — Statehood Day — and as a 19-point underdog, knocked off the No. 2 Sooners and halted one of the most celebrated streaks in sports.
When the Sooners played at Notre Dame in '99, some 6,000 OU fans made the trip to South Bend.
Beyond the fan bases, OU-Notre Dame matchups also create a stir nationally. The Irish have won 11 national championships, more than any school. The Sooners have won seven national titles — all since 1950.
"Certainly, there haven't been a huge number of games in the series,” Heisler said. "That's what makes it a little intriguing, because you have two names that have been pretty high profile a long number of years.
"When they aren't routine appearances, it grabs more attention.”