It was all too-little, too-late for the Pacers, who suffered their worst loss of the season. Their only other losses were by 16 points at Chicago on Nov. 16 and by four points at Portland on Dec. 2.
"I wouldn't say we had tired legs, but the Thunder definitely knew what we were up against," George said. "They knew this was a back-to-back night for us. They came out with that urgency to really run us, and see if we could compete and match their energy."
The Thunder swept the regular-season series with Indiana last season, and they nearly equaled their season-high of 119 points in the win — falling one point short of what they scored on Nov. 8 against Detroit.
Oklahoma City led by as many as 14 points in the first quarter, stretching that to 19 points in the second quarter after Jeremy Lamb's 3-pointer put the Thunder up 43-24.
Lamb's 3-pointer capped a 15-4 run for Oklahoma City, all coming from its reserves — led by Jackson's seven point.
The Thunder shot 54.8 percent (23 of 42) in the first half, while Indiana shot just 32.6 percent (15 of 46).
"Tonight, obviously, for our guys, Oklahoma City was just a step quicker on both ends of the court," Indiana coach Frank Vogel said.
NOTES: Indiana finished a five-game trip against the Thunder, going 3-2 on the road with losses to Oklahoma City and Portland. ... The Pacers, who played two of the top Western Conference teams in San Antonio and Oklahoma City in their last two games, return home to face two-time defending NBA champion Miami on Tuesday.