Zuckerberg met Chan at Harvard, where he founded Facebook in a dorm room in 2004, and have been together for more than nine years.
Chan's own Facebook page, which now lists her as married to the founder, said she is a native of Braintree, Mass., and attended high school in nearby Quincy.
She graduated Harvard in 2007 then taught science to fourth and fifth graders at the Harker School in San Jose for two years before starting medical school, according to her profile.
Her page also says she "loves cooking and soft things."
Even after the IPO, Zuckerberg, who grew up in Dobbs Ferry, N.Y., remains Facebook's single largest shareholder, with 503.6 million shares, and he controls the company with 56 percent of its voting stock.
The site has grown into a worldwide network of almost a billion people and made its founder, Time magazine's Person of the Year in 2010, one of the most famous businessmen of the Internet age.
Associated Press Writer Andrew Dalton contributed to this story from Los Angeles.