The wreck occurred southwest of Beaumont, on Texas' Gulf Coast. The heavy fog made it hard for law enforcement to determine at first how many wrecks had occurred.
According to the Texas Department of Public Safety, a crash on the eastbound side of the highway led to other accidents in a dangerous chain reaction. There were multiple crashes on the other side of the highway as well.
Texas Department of Public Safety Sgt. Chuck Havard told KFDM-TV on Friday that investigators will work to determine whether any drivers will face charges.
Phone messages left Friday by The Associated Press for law enforcement officials weren't returned.