Article Photos: Bills set another new low in 45-3 loss at 49ers

San Francisco 49ers quarterback Alex Smith (11) passes against the Buffalo Bills during the first quarter of an NFL football game, Sunday, Oct. 7, 2012, in San Francisco. (AP Photo/Tony Avelar)

San Francisco 49ers quarterback Alex Smith (11) passes against the Buffalo Bills during the first quarter of an NFL football game, Sunday, Oct. 7, 2012, in San Francisco. (AP Photo/Tony Avelar)