49ers offense seeks another big day against Giants - Article Photos 4/5

San Francisco 49ers quarterback Alex Smith (11) passes as Buffalo Bills linebacker Kelvin Sheppard (55) applies pressure during the second half of an NFL football game in San Francisco, Sunday, Oct. 7, 2012. The 49ers won 45-3. Smith threw for a season-high 303 yards and three touchdowns. (AP Photo/Ben Margot)