Lance Stephenson scored two more free throws to put the game out of reach.
The Grizzlies led 67-60 heading into the fourth quarter.
Ben Hansbrough hit two 3-pointers and the Grizzlies' Darrell Arthur scored a basket, but the Pacers trailed by just three, 69-66.
"I just thought we got a lot more active defensively," West said. "We were much more precise in terms of our communication and what we wanted to do defensively. And guys stepped up and made shots."
George had a key steal and dunk, and West's free throws gave the Pacers the lead for good. The Grizzlies turned the ball over and West made two more foul shots to make it 74-71 with 5:37 left.
"We had it in our clutches and our first four of six posessions in the fourth quarter were turnovers," Grizzlies coach Lionel Hollins said. "We quit pushing the ball once we got the lead. It wasn't pretty."
The Grizzlies' ended a five-game winning streak over Indiana and wrap-up a two-game road trip at Boston on Wednesday.
NOTES: Stephenson was listed as day to day with a left orbital contusion, but started. ... Grizzlies F Quincy Pondexter didn't travel with the team because of a left MCL sprain. ... Hibbert's first offensive rebound of the night was his 800th career. ... Indiana Fever forward Katie Douglas attended the game and was recognized for the Fever's recent WNBA championship.