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Getting to the heart of Alzheimer's

What effect does blood pressure have on an individual’s susceptibility to Alzheimer’s?
by OMRF Modified: March 5, 2014 at 11:59 am •  Published: March 4, 2014

Adam's journal

These days, we're so busy answering questions from readers that I never get to ask my own. Maybe next month!

Dear Dr. Prescott,

Has the Oklahoma Medical Research Foundation looked into whether lowering people's blood pressure could be contributing to the rising rates of Alzheimer's disease?

My thinking is that the body naturally increases its blood pressure in response to a specific need, such as poorer circulation brought on by age. So could blood pressure-lowing medications have the effect of reducing the amount of blood — and oxygen — reaching the brain?

— Dick, Stillwater

Dr. Prescott prescribes

Blood pressure is the force applied against the walls of the arteries as the heart pumps blood through the body. High blood pressure, or hypertension, results when the blood flow exerts excessive force against arterial walls.

Typically, this increased force is caused not by a specific need — such as the need for more oxygen in the brain — but because muscles in the walls of the arteries contract and cause the arteries to narrow. When this happens, the heart continues to pump with the same strength as if your arteries are unconstricted. But, in fact, it is now pushing the blood through a smaller space.

Just think about a hose hooked to a spigot. If you stick your thumb over half of the opening, what happens to the water? For the same amount of water to come out, there has to be a greater force in the hose. That's what's happening with high blood pressure.

While your body can tolerate elevated blood pressure for months, even years, the excessive force eventually can cause damage to your heart, kidneys and eyes. And brain.

Studies have found that people suffering from untreated high blood pressure are more likely to develop memory and cognition problems. But when patients who displayed vascular problems were treated, they showed a 40 percent lower risk of subsequently developing Alzheimer's than those who were not.

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Founded in 1946, the Oklahoma Medical Research Foundation is one of the nation’s oldest and most respected nonprofit biomedical research institutes. Located in Oklahoma City, OMRF fosters a worldwide reputation for excellence by following an...
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