"Latos was fine," Reds manager Dusty Baker said. "Before the game he was coughing. He had to get his work in. He didn't throw the ball bad."
Shin-Soo Choo and Brandon Phillips singled off Santana to start the game in front of Votto's tangled-up double.
Ryan Hanigan doubled and scored on a single by Latos. The Reds loaded the bases but Santana got Votto to hit a one-hop ground ball to the mound that resulted in a 1-2-3 double play.
The Reds squandered other chances and didn't score until minor leaguer Bryson Smith homered off Dan Wheeler in the ninth.
"We should have had eight runs," Baker said. "We left second and third twice, bases loaded. We had a lot of opportunities to break that game open. It's got to get better picking up those runs. It's frustrating sometimes."
NOTES: The Royals optioned RHP Louis Coleman to Triple-A Omaha. ... The Royals reassigned RHP Wheeler and INF/C Max Ramirez to the minor-league camp. ... The Royals began the game hitting .336 as a team this spring. It is tops in the big league, 27 points higher than the next-closest team. ... LHP Manny Parra, who signed as a free agent with the Reds in January, is trying to make the team as its third left-hander. Parra allowed three runs on five hits in two innings. He has a 5.28 ERA for the spring. ... RHP J.J. Hoover has 18 strikeouts in nine innings, while walking two. ... Minor league RHP Loek Van Mil appeared in the game for the Reds. The 28-year old native of the Netherlands is 7-foot-1 and is the tallest player in professional baseball. ... INF Cesar Izturis, trying to win a spot as a reserve with the Reds, singled in two trips. The veteran is hitting .340 for the spring. ... C Miguel Olivo was released from his minor-league contract by the Reds and he subsequently agreed to terms with Miami.