Oklahoma City Mayor Mick Cornett did a rehearsal at the convention site, the Tampa Bay Times Forum, for his Tuesday speech, now expected to be delivered at 3:10 p.m. Central time.
The storm is expected to strengthen into a hurricane and hit parts of the Gulf Coast by Wednesday.
Fallin said it was too early to tell whether the convention would be affected again by Isaac.
“We'll just have to wait and see what the storm actually does,” she said. “We certainly want to keep people safe across the nation, and we're very mindful that just seven years ago New Orleans was struck by a terrible hurricane that did so much damage.
“We're just hopeful and prayerful that it will be easier on them than what it has been in the past.
“But in the meantime, electing a president is the business of the nation, too. Hopefully, we'll be able to do both — keeping people safe from the hurricane and running a successful convention at the same time.”