Memorial (3-6, 3-3 in District 6A-4) managed only 160 yards of total offense in the game, just 72 in the first half as the Wolves led 35-0 at halftime.
Meanwhile, Santa Fe rolled up 411 yards of total offense in the first half as Hansen tossed three touchdown passes and rushed for another.
By halftime, Hansen already was 11 of 18 for 220 yards through the air while rushing for 106 yards on 11 carries.
Hansen tossed two more touchdown passes before leaving the game late in the third period. He finished the night 14 of 22 passing and 278 yards, plus rushing for 153 yards on 15 carries.
“I think we take for granted that is what he is supposed to do,” Manning said of Hansen. “He is consistently productive out here on Friday nights.”
Trevan Smith caught touchdown passes of 43 and 21 yards, while Calvin Harkless also had scoring receptions of 43 and 29 yards.
Memorial still has a chance to make the playoffs with a win next week. It was the 13th straight district victory for Santa Fe (8-1, 6-0 in district play).
“To me, that's special,” Manning said. “With the teams we've been playing, that says a lot ... This is when you want to be playing your best football, and right now I think we are.”