Edmond North's Jared Benway suffered a major leg injury in the team's scrimmage Saturday.
Benway was expected to be the team's feature back and played a key role in the Huskies' running game last year as a sophomore.
"We have to do it now (adapt). We have to be creative," coach Jeremy Dombek said. "It's no secret that Jared was our horse, but he's just a junior. He'll be back."
Dombek said the injury is not related to the high ankle sprain Benway had during the spring and summer but would not comment any further on it except to say Benway will be out indefinitely.
The Huskies will get their first chance to adapt to the situation Friday night with a scrimmage vs. Moore at Edmond North.
PC North's Holman out 3-5 weeks after knee surgery
Putnam City North junior running back Dre Holman could miss the first couple games of the season after suffering a partially torn meniscus on the first day of football practice last week.
Holman underwent surgery to repair the knee Monday morning.
The Panthers were preparing for a season with two standout running backs in Holman and senior Sam Wolfe.
The position was ravaged by injury last season as well, with Holman missing the first three games of the year with a high ankle sprain suffered in the first days of practice. In the second game of the season, Wolfe broke his collarbone and missed the rest of the year.
After returning from last season's ankle injury, Holman rushed for 942 yards and seven touchdowns.
Lawton's Cooper out, Bowles back
Lawton coach Randy Breeze said he was pleased with the first week of practice, but the Wolverines did lose a key piece to the puzzle.
In a non-contact drill, senior Trevon Cooper tore his ACL and will miss the rest of the season.
The ACL also played a big role for Brett Bowles, but his was a happier story. Bowles returned to the field for the first time since tearing his ACL last year. Breeze said Bowles looked sharp in the team's 133-play scrimmage this weekend.
Breeze said a big thing has been the depth of the team. He said about 90 players have been participating.
"That's going to allow us do more things than what we've been able to do in the past," Breeze said.
Prague preparing without QB Simek
Prague coach Charles Atchison saw great promise in his backfield, with two talented running backs and a returning quarterback in junior Clint Simek.
That is, until Simek tore his ACL at team camp in June.
Last season, it was Simek's older brother, Denton, who suffered a torn ACL and was sidelined for much of the season. Denton Simek is now a freshman offensive lineman at Arkansas.
"It was a non-contact injury, just a freak deal," Atchison said of Clint Simek's injury. "He's two months out from surgery and he might even be able to come back for the last part of the season, Week 9 or 10, but we'll have to see. I think he can have an incredible senior year."
Even without his quarterback, Atchison is still pleased with his run game, led by backs Dalean McClendon and Tyler Duncan.
"I think we'll be able to run the football," Atchison said. "We're bigger up front than we've been. The kids are responding good — there have been a couple other kids step up. We're real young, but we've still got a chance to win some ballgames."