Bodemeister, trained by three-time Derby winner Bob Baffert, was second and returned $6.20 and $5.60. Dullahan was a neck back in third and paid $7.20 to show.
Trainer Doug O'Neill didn't waste any time vowing that I'll Have Another will go on to the Preakness in two weeks.
“Maryland, here we come baby!” he said.
I'll Have Another made his way to the starting gate accompanied by his stable pony, Lava Man, another cheap purchase turned into a career winner of more than $5 million by O'Neill. The trainer has made his name predominantly in Southern California, although he's won three Breeders' Cup races.
One of his best horses, Steviewonderboy, was the winter favorite for the 2006 Derby before being sidelined by injuries early that year.