Wayne Ellington started for Waiters and Marreese Speights filled for Zeller. Waiters was named the NBA's Eastern Conference Rookie of the Month for February after averaging 15.8 points.
The Cavs went 2-1 last week without Irving, who has missed 14 games in his second NBA season because of injuries. He banged knees in practice last month with teammate Omri Casspi. Irving missed 11 games with a broken index finger earlier this season, and played several weeks wearing a protective mask after breaking his jaw.
He also missed games last season with assorted injuries, and Irving played in only 11 games as a freshman at Duke because he tore a tendon in his foot.
Scott dismissed the notion Irving is injury prone.
"He's 20 years old and his body hasn't fully developed," Scott said. "He's got a long career ahead of him and the injuries he's getting are just unavoidable. It happens in the flow of a basketball game or practice. He's not injury prone. It's no big deal."
The NBA's Rookie of the Year in 2012, Irving is averaging 23.3 points, 5.6 assists and 3.6 rebounds.