Jacksonville rookie offensive tackle Luke Joeckel will miss the rest of the season because of a broken right ankle.
The No. 2 overall draft pick in April was injured in the first quarter of a 34-20 loss to the Rams on Sunday. He was taken off the field on a cart.
Joeckel got his leg rolled up by Rams defensive tackle Kendall Langford at the end of a 1-yard carry by Maurice Jones-Drew.
"I saw it happen and it's unfortunate," said quarterback Blaine Gabbert, who also left the game with an injury. "It wasn't pretty."
Gabbert strained his left hamstring in the third quarter. Playing in his hometown, he was 9 of 19 for 181 yards with one touchdown and two interceptions before leaving.
Jaguars tight end Allen Reisner left the game in the third quarter with a sprained knee.
Philadelphia Eagles quarterback Michael Vick left the game against the New York Giants with a left hamstring injury.
Vick grabbed his left hamstring while gaining 13 yards on a running play in the second quarter. He finished that series and began the Eagles' next possession, but left after one incomplete pass.
Nick Foles replaced Vick and led Philadelphia to a 36-21 victory.
Giants running back David Wilson left after the final play of the first period with a neck injury and did not return.
Green Bay linebacker Clay Matthews left the Packers' 22-9 win over Detroit after the third quarter with a thumb injury.
Matthews sacked Matthew Stafford on the last play of the quarter on a third-and-9 at the 34 to push the Lions out of field-goal range. He jogged to the locker room with a trainer and did not return.