The night was punctuated in the third quarter when Wade threw a pass off the glass to a soaring James for a 71-57 lead.
"He came out with force," Spoelstra said of James. "And it was on both ends. He was active, he was over the top with his athleticism. Some of the rebounds were up over the crowd, playing out of the post, but also in transition playing in a different motor."
Wade missed the previous two games, first with knee soreness and then because of an illness. He suffered a scare in the first quarter when he appeared to bang his right knee as he crashed to the court. He writhed in pain for a few minutes, but was able to get up and keep going.
The Heat play at Detroit on Sunday, but it wasn't certain that Wade would play. Spoelstra likes to rest him on back-to-backs to reduce the wear and tear on his knees.
Nikola Pekovic had 18 points and 12 rebounds for the Wolves, who were playing after a game against San Antonio in Mexico City on Wednesday night was postponed due to smoke in the arena.
Minnesota point guard Ricky Rubio struggled mightily with one point on 0-for-4 shooting, six assists and six turnovers.
"It seems like we were scared," Rubio said. "That can't happen."
NOTES: Chris Bosh had nine rebounds for the Heat. ... Love is expected to practice Sunday and be in uniform for the Wolves' next game against the Pistons on Tuesday. ... The Heat stayed in a hotel just across the street from the arena, but took a bus for the morning shootaround as most teams do. Spoelstra usually walks when he's here. But a wind chill that dipped to 15-below zero made him think otherwise. "I had to make it from the door to the bus," Spoelstra said. "Those 10 steps were about as tough as it gets."