He was two blocks shy of a triple-double against Oklahoma State, and he still managed 11 points and 12 rebounds last week against West Virginia despite dealing with pain.
Embiid hasn't played more than 17 minutes in any of his last three games.
"He's looking around to see if he's going to get hit as opposed to initiating contact because he's sore and hurts in different areas, so yeah, I think there's certainly some signs he hasn't been himself," Self said. "But like I said before, it would be like to me if you're a running back and your high ankle sprain hasn't totally healed but you could go out there."
In other news, Self said he planned to sit down with reserve forward Jamari Traylor on Thursday to discuss his status for Saturday's game. Traylor sat out Monday night's game for what Self called disciplinary reasons.
"Jamari and I are going to visit today, and I'll hold off on that until after we visit," Self said. "But I certainly anticipate that visit going well."