COLUMBIA, Mo. — Joseph Randle scored four touchdowns, two on runs that capitalized on big defensive plays by Shaun Lewis, as No. 6 Oklahoma State remained unbeaten and ended Missouri's 10-game home winning streak with a 45-24 victory on Saturday.
Randle had 138 yards on 14 carries and scored on runs of 16, 59 and 12 yards. He also caught a 13-yard touchdown pass in the second quarter.
Brandon Weeden had three touchdown passes after the opening snap of the second quarter. Lewis' interception and fumble recovery helped the Cowboys (7-0, 4-0 Big 12) pull away despite injuries to both starting wide receivers.
Justin Blackmon caught a touchdown pass in the first quarter before hurting his right shoulder. Hubert Anyiam was wearing a boot on his left foot in the second half.
Henry Josey had 138 yards on 25 carries and T.J. Moe had six catches for 103 yards and a score for Missouri (3-4, 1-3), which has yet to win consecutive games.
The Tigers had a strong second quarter, scoring on an 18-yard run by Kendial Lawrence and Moe's 34-yard catch from James Franklin to cut the deficit to seven, before being undone by mistakes. Franklin threw two interceptions and lost a fumble at the Oklahoma State 4, all in the second half.
Lewis intercepted a tipped pass at the Missouri 27 and three plays later Randle scored on a 16-yard run for a two-touchdown cushion midway through the third quarter.