But the tone was set from the start, as Keselowski and Logano justified their front-row qualifying sweep with a vengeance. Keselowski wasted no time with that agenda, taking charge at the green flag and leading the first 78 laps before Logano took over for five laps.
The two traded leads from there with nobody else to challenge them until Aric Almirola's wreck brought the sixth caution on Lap 213.
That sent the leaders down pit road and scramble off produced the race's first non-Penske leader in Busch, whose No. 18 took over on Lap 217 and led the restart with Newman second.
The Penske duo needed just seven laps to draw a bead on both drivers and Keselowski was soon second and making a furious effort trying to chase down Busch, who had a 2-second lead at one point. Once Keselowski caught him in the backstretch, he again showed his Ford's superiority.
"Our car was awesome," said Keselowski, who has led a series-high 346 laps in four starts at Kentucky.
Earnhardt, Jimmie Johnson and Tony Stewart meanwhile overcame bad starting spots to finish in the top 11. Johnson was 10th after starting 25th and Stewart recovered from a 42nd-place start because of a transmission change for 11th. He had qualified 13th.
"I would have liked to have been a little better than what we were there at the end," Stewart said, "but I think we definitely had to fight our way up through the day. .. All in all I thought we had a pretty honest day there; can't complain about that."
Points leader Jeff Gordon finished sixth and leads Johnson and Earnhardt by 24.