— 2005: Begins two-year term as chairman of Senate Judiciary Committee.
— February 2009: Votes for Democrats' economic stimulus package, inflaming GOP sentiment against him.
— April 15, 2009: Toomey announces he will mount another challenge to Specter in 2010 Senate GOP primary.
— April 28, 2009: Specter announces he is changing party registration from Republican to Democrat.
— August 4, 2009: Democratic U.S. Rep. Joe Sestak announces his Senate candidacy.
— May 18, 2010: Sestak defeats Specter in Democratic Party primary.
— Dec. 22, 2010: Specter takes last vote in Senate.
— Jan. 3, 2011: Senate term ends.
— Oct. 19, 2011: In speech, Specter blames the tea party for removing GOP moderates, says Washington gridlock has become "like a war."
—Aug. 28, 2012: Confirms that he is battling cancer again, calls it "another battle I intend to win."
—Oct. 14, 2012: Son confirms Specter's death at his Philadelphia home of complications of non-Hodgkin lymphoma.
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