J.J. Hickson had 22 points and 11 rebounds for Portland, and Nicolas Batum also scored 22. Two-time All-Star LaMarcus Aldridge finished with 15 points in 34 foul-plagued minutes after picking up his fifth personal with 8 minutes remaining.
Damian Lillard added 19 points. All of Portland's starters scored in double figures, while the bench produced just 14.
Hickson, who came in fifth in the NBA with a 56.5 field goal percentage, shot 8 for 10 in the first half and had 16 points — including a 20-footer with 2.6 seconds on the clock to give the Blazers a 55-53 lead at the break.
"I like the way our team fought," Portland coach Terry Stotts said. "We've had a rough stretch, but we came out and played aggressively. We pushed the tempo and did a lot of good things out there. I thought we played well enough to win the game, but unfortunately we didn't."
NOTES: The Lakers (27-29) haven't been under .500 this deep into a season since 1993-94, when they were 21-35 after 56 games and finished 33-49. That was the first of only two times that the team didn't make the playoffs during Buss' term as owner, which began in 1979-80. ... The Lakers are 5-13 when Bryant commits five or more turnovers. ... Bryant hit a 3-pointer in the first quarter that snapped his string of 16 consecutive misses from behind the arc. He is only 2 for 39 since Jan. 20, when he misfired on his last two attempts. "I didn't realize I was shooting so poorly from the 3," Bryant said. "It was one of those things where I was facilitating and taking a 3 here and there, a 3 here and there. All of a sudden, it adds up. It just irked me it's not going down." ... Hickson was 11 for 15 from the field, extending his club-record streak to 18 consecutive games of shooting 50 percent or better. ... No Lakers player scored 30 or more points in the team's previous 17 games since Jan. 15, when Bryant and Howard each had 31 in a 104-88 home win against Milwaukee. ... The Blazers haven't lost more than seven straight games in the same season since 2005-06, when they dropped their final eight and 19 of their last 20. They begin a four-game homestand Sunday against the Celtics, who have beaten Portland six straight times and won 13 of the past 14 meetings. ... The Blazers have lost six straight road games against the Lakers, and are 5-20 against them at Staples Center since the arena opened in 1999-00.