James was the only Miami player to start the team's first 29 games.
"When he's in the game we rely so much on him offensively and when he is out of the game our package is so much different," Wade said. "We just wanted everyone to be aggressive."
During the Sacramento loss, James passed Larry Bird (21,791 points) and Gary Payton (21,813 points) to move into 29th place on the NBA's career scoring list.
With 21,819 points, the next player in front of James is Clyde Drexler at 22,195.
James has given the Blazers trouble at the newly renamed Moda Center. In 10 games in Portland, he has averaged 29.6 points, 9.9 rebounds and 7.2 assists.
He is listed as day-to-day. He turns 29 on Monday when the Heat play at Denver to wrap up a four-game trip.