After registering his third triple-double of the season and seventh since joining the Heat, James got a mixture of cheers and boos when he went to the bench with 10:15 left.
Wade came in after a brief rest and continued his hot shooting, scoring six straight points on a driving layup, two free throws and a long jumper. He was 12 of 14 at that point before missing a 3-pointer.
"I think we're better than last season because we understand each other a lot more," Bosh said. "Everyone is coming together as a team and we feel comfortable with each other. I think we're starting to play like we know we're capable of playing. It's shown in this win streak. Even with the break, we've continued to play well. I think if we keep playing at this type of level, the sky is the limit for us."
While the Heat are gearing up to make a run at a repeat, the Sixers have lost four straight to fall a season-worst nine games below .500 at 22-31.
"In the first half, we did a lot of things well," Holiday said. "We have to sustain that for 48 minutes."
It's been a disappointing year for Philadelphia, which knocked off top-seeded Chicago in the first round of the playoffs a year ago and then took Boston to seven games in the conference quarterfinals.
A season that began with promise after the acquisition of center Andrew Bynum quickly fell apart. Bynum has yet to play a game this season because of bone bruises in both knees. He said earlier in the week he plans to play at some point. At this rate, it won't matter much for the Sixers.
"Holiday is a great player, but he needs help," James said. "We all thought Bynum would be a huge piece for them."
Notes: The Flyers beat the Winnipeg Jets 5-3 in an afternoon hockey game. ... The Heat have won 12 straight regular-season games against Philadelphia. The Sixers won one playoff game against Miami in the first round of the 2011 playoffs. ... Heat G Mike Miller remained in Miami because of ear problems resulting from a head cold. He's missed three straight games. ... James has scored in double figures in 472 straight games, sixth-best in NBA history.