“By Tuesday morning, we're looking at a low in the upper 20s and of course there's going to be a windchill too, around the 20s,” Pike said.
Northwest Oklahoma also saw the worst of last week's winter weather, with some areas getting a foot of snow or more.
State and local road crews are on alert, officials said, and emergency responders urge people to prepare for a life-threatening blizzard.
Pike said Interstate 40 westbound to the Texas state line will receive the worst conditions of major thoroughfares, but Interstate 35 north of the metro could be troublesome as well.
Red Cross spokesman Ken Garcia said the agency is prepared to send volunteers wherever they might be needed in the state.