"I felt that changed the inning for me," Quintana said through a translator. "It kind of took the wrong way for me with that error."
The Mariners then strung together five consecutive hits to chase Quintana and open a 6-1 lead. Gutierrez had a two-run double and scored on Saunders' triple. Morales added an RBI single, stopping a 1-for-14 slide.
But the White Sox responded with four runs in the bottom half and another in the seventh. De Aza hit a two-run shot and Rios had a solo drive in the fifth, and Rios' grounder brought home Gordon Beckham with the tying run two innings later.
"The good part about tonight is it's over, basically," White Sox slugger Adam Dunn said. "It was miserable out there for everybody. We had our chances and it didn't happen. We'll come out tomorrow and hopefully get 'em."
Gutierrez got the Mariners off to a nice start when he drove Quintana's fourth pitch just over the wall in the right-field corner. It was Gutierrez's second leadoff homer of the season and No. 3 for his career.
"Just trying to get on base. That's it," Gutierrez said. "Obviously in the leadoff spot, when the game starts they throw more fastballs so I'm trying to be ready for that. If I hit it good, it can go out."
NOTES: The game-time temperature was 34 degrees. ... Mariners ace Felix Hernandez will make his second start on Saturday. The right-hander gave up three hits over 7 2-3 innings in a 2-0 win at Oakland on opening day. He will be opposed by RHP Dylan Axelrod, who will be making his season debut. ... With the short turnaround between games, Konerko likely will get a day off on Saturday. Chicago manager Robin Ventura also said C Hector Gimenez probably will play. ... Wedge said C Kelly Shoppach likely will be in the lineup on Saturday.
Jay Cohen can be reached at http://www.twitter.com/jcohenap