But there were many more blunders than highlights, as the Jaguars went over 36 minutes without a first down and didn't generate any offense until the game was out of hand.
One of the most egregious mistakes came when D.J. Williams lined up in the neutral zone on a punt, prolonging a third-quarter drive that ended in a field goal by Janikowski that made it 13-3.
Jason Babin also prolonged two scoring drives with penalties to help Pryor get his first win as an NFL starter in his third start.
Pryor, who beat out Matt Flynn for the starting job in training camp, was much less spectacular than he was a week ago in Indianapolis, when he recorded the eighth 200-yard passing, 100-yard rushing game since the 1970 merger.
But he also avoided many of the mistakes that plagued him a week ago, when his two interceptions contributed to a 21-17 loss. The threat of his running also opened up big lanes for McFadden.
"Knowing that you have to defend him going around the edge, a couple plays they left the middle wide open and I was able to get up in there and get some big runs out of it," McFadden said.
The Raiders started fast, forcing a three-and-out on Jacksonville's first possession and converting a short field after Phillip Adams' 30-yard punt return.
They scored their first opening-drive touchdown since the final game of the 2011 season. Aided by a personal foul on Babin, Oakland took a 7-0 lead on Reece's 11-yard run.
There wasn't much offense the rest of the game. Pryor did not complete a pass past the line of scrimmage in the first 27 minutes, and Henne struggled to move the Jaguars down the field until late.
NOTES: Raiders S Tyvon Branch left in the first quarter with a "significant" ankle injury. ... Janikowski missed a 35-yard field goal attempt in the first half, ending a streak of 50 straight makes under 40 yards. ... The Jaguars had 34 yards rushing for their lowest total since gaining 33 in the season opener against Tennessee in 2008.
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