Defensive tackle Johnathan Hankins and cornerback Bradley Roby will likely look into leaving a year early to go into the NFL draft. Meyer said he will counsel them if and when they come to him.
Star quarterback Braxton Miller will likely be one of the Heisman Trophy front-runners next year as a junior. But he will also be challenged.
"If he becomes the best (in fundamentals) in America I think he will be the best quarterback in America," Meyer said. "It'll be comical what he'll do. But he's not there yet."
With an exemplary crop of seniors leaving, that means it's up to the rest to follow their lead.
Adolphus Washington, a freshman who forced a key fumble in the Michigan game, will likely take over for Simon.
"That was the hardest group of workers I've ever seen in my life," he said of the seniors. "It's a foundation to keep the tradition going, to just keep working hard."
Meyer, meanwhile, is energized by what his players accomplished. He had twice stepped aside while the head coach at Florida, citing health and family issues. Some thought he was another Type A personality who burned out.
He said he learned a lot from the faith and trust his players had in the coaches.
Meyer also said he had changed from the workaholic coach who was obsessed with his team and all but forgot about his family during a season.
Before taking the Ohio State job, his two college-age daughters, Nicole and Gigi, his son in middle-school, Nate, and his wife, Shelley, made him sign a contract on a pink sheet of note paper that he wouldn't overdo it this time, that he would remember his personal life had precedence over his professional life.
"Every Sunday I busted out of here at noon and went and watched my son play football. That would have never happened (before)," he said.
He even has proof — two tickets he got for running stop lights to get to one of Nate's games.
"I was 15 minutes late and getting texts from my wife saying, 'You'd better get here.' So I went through a couple of red lights. That's 50 bucks or whatever it is," he said with a laugh. "Great story, isn't it?"
Follow Rusty Miller on Twitter: http://www.twitter.com/rustymillerap